David, welcome to the board!
Shortly - Yes but it's not VOX but macOS who does this. We only need to make sure VOX does not interfere:
To achieve what You need - in VOX, Preferences -> Audio, make sure that "Sync Sample Rate" option is OFF. This way VOX does not alter the sample rate/format of the device in any way.
Next, go to Audio Midi Setup (in macOS), select Your output and select required sample rate and sample format.
Tell us if this worked for You, welcome if You have any questions.